The Nisshin Seifun Group (Nisshin Flour Milling) medicinal segment (presently Nisshin Pharma INC) was the first company in the world to develop a manufacturing method for CoQ10 in 1966.
It was sold as a medical supply, “Neuquinon” (medicine for congestive heart failure), for the first time in 1974. Although it was widespread in the United States as an antioxidant supplement from early on, it was approved for sale as a food product in 2001. It became a smash hit in Japan from its inception.
Japan is the only CoQ10 producing country with five companies responsible for production: Kaneka (world share about 70%) and Nisshin Pharma, Asahi Kasei Pharma, Kyowa Hakko Kogyo Co., LTD, and Mitsubishi Gas Chemical Company INC.