Seiji Shinkai: Discovery of nanoscale machinery and microelectronics that are capable of obeying orders.

At the beginning of the 1980’s, Seiji Shinkai succeeded in creating a “supermolecule” (molecular nano-machine) that can be manipulated in the same way that meter sized or centimeter sized machines can. He developed methods of making atoms and molecules assemble, form a structure and function cooperatively.

He also succeeded in developing a sensor that can analyze blood sodium to a high-degree of accuracy in 1993. This application developed into technology by which DNA memory was carved on a print base (chip) becoming the basis for nanotechnology.

Moreover, He discovered that Shizophyllan derived from a mushroom, Suehirotake, could form a triple helixical complex with a single-stranded polynucleotide for the first time. New research where DNA effective for cancer therapy is amplified and carried into cancer cells with a polysaccharide is on going.

References

Seiji Shinkai

KYUDAI NEWS No.14 Page 1-4

Takahisa A, Kazuo S, Shinkai S: A new polynucleotide-polysaccharide complex and its application to functional oligonucleotide delivery. Trends in Glycoscience and Glycotechnology 17:49-57, 2005.